Ingredient guide
Spermidine (from wheat germ extract): evidence, dose and safety
Spermidine is a polyamine found in wheat germ, soy, mushrooms and aged cheese. Ours comes from a wheat germ extract authorised as a novel food in the EU.
At a glance
- Strongest evidence
- D Weak
- Adult upper limit
- 6 mg a day from food and supplements together
- Safety checks
- 1 situation and 0 medicine or supplement interactions, checked against your answers in every plan
- Reviewed
- Atrum Labs clinical team (MD, PhD), November 2026
What the research looked at
Each line is one body of research, graded A (strong) to D (weak). How we grade evidence. What each study measured is explained in your personal plan.
| Grade | Who was studied | References |
|---|---|---|
| D | Older adults with subjective cognitive decline |
|
How much
- Adult upper limit: 6 mg a day from food and supplements together. Source: Union list (Reg. (EU) 2017/2470) conditions of use for spermidine-rich wheat germ extract; exact entry to be copy-checked.
- Children's doses are set by age, and some ingredients are for adults only.
Who should not take it, or should check first
- Not suitable. No safety data in pregnancy or breastfeeding.
Products with Spermidine (from wheat germ extract)
Written and reviewed by the Atrum Labs clinical team (physician-scientists, MD, PhD) from our clinical knowledge base, version 0.2.0-draft. This page is general information, not medical advice. Food supplements are not a substitute for a varied, balanced diet and a healthy lifestyle.
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